Table 1.
Correlation of paired CSF and serum analytes at baseline, 1-week, and 2-week post cryptococcal meningitis diagnosis.
| Biomarker | At CM diagnosis | 1-week post diagnosis | 2-week post-CM diagnosis | ||||||
|---|---|---|---|---|---|---|---|---|---|
| N | Rho | p value | N | Rho | p value | N | Rho | p value | |
| Innate immune response | |||||||||
| IL-6 | 160 | 0.021 | 0.79 | 105 | -0.025 | 0.80 | 115 | -0.228 | 0.01 |
| IL-1β | 160 | -0.042 | 0.60 | 105 | -0.122 | 0.22 | 115 | 0.052 | 0.58 |
| IL-8 | 160 | -0.034 | 0.67 | 105 | 0.141 | 0.15 | 115 | 0.035 | 0.71 |
| G-CSF | 160 | -0.003 | 0.97 | 105 | 0.1 | 0.31 | 115 | 0.087 | 0.36 |
| GM-CSF | 160 | 0.033 | 0.68 | 105 | 0.16 | 0.10 | 115 | 0.25 | 0.007∗ |
| MCP-1 | 160 | 0.133 | 0.09 | 105 | 0.216 | 0.03 | 115 | -0.117 | 0.21 |
| MIP-1α | 75 | 0.01 | 0.93 | 5 | 0.4 | 0.51 | 93 | -0.07 | 0.51 |
| MIP-1β | 160 | 0.117 | 0.14 | 105 | 0.114 | 0.25 | 115 | -0.057 | 0.55 |
| CD14 | 87 | 0.078 | 0.47 | n | N/A | N/A | 83 | 0.187 | 0.09 |
| CD163 | 87 | -0.249 | 0.02 | n | N/A | N/A | 83 | -0.099 | 0.38 |
| Adaptive immune response | |||||||||
| IFN-γ | 160 | -0.214 | 0.007∗ | 105 | 0.089 | 0.37 | 115 | 0.198 | 0.03 |
| TNF-α | 160 | 0.077 | 0.33 | 105 | 0.038 | 0.70 | 115 | 0.078 | 0.41 |
| IL-12 | 160 | 0.09 | 0.26 | 105 | -0.153 | 0.12 | 115 | -0.005 | 0.96 |
| IL-2 | 160 | -0.025 | 0.76 | 105 | -0.041 | 0.68 | 115 | 0.22 | 0.02 |
| IL-7 | 160 | 0.038 | 0.64 | 105 | 0.11 | 0.26 | 115 | -0.004 | 0.96 |
| IL-10 | 160 | 0.021 | 0.80 | 105 | 0.045 | 0.65 | 115 | -0.025 | 0.80 |
| IL-5 | 160 | -0.046 | 0.56 | 105 | 0.099 | 0.32 | 115 | 0.004 | 0.97 |
| IL-4 | 160 | -0.232 | 0.003∗ | 105 | 0.107 | 0.28 | 115 | -0.064 | 0.49 |
| IL-13 | 160 | 0.056 | 0.48 | 105 | -0.004 | 0.97 | 115 | -0.057 | 0.54 |
| IL-17 | 160 | -0.008 | 0.92 | 105 | 0.128 | 0.19 | 115 | 0.012 | 0.90 |
| Hemostasis | |||||||||
| VEGF | 111 | -0.049 | 0.61 | 62 | 0.062 | 0.63 | 115 | -0.002 | 0.99 |
∗ p value of less than 0.01. Interleukin: IL; interferon: IFN; tumor-necrosis factor: TNF; granulocyte colony-stimulating factor: G-CSF; granulocyte-macrophage colony-stimulating factor: GM-CSF; monocyte chemoattractant protein-1/CCL2: MCP-1; macrophage inflammatory protein: MIP; and vascular endothelial growth factor: VEGF.