Table 2.
Correlation of CSF and serum cytokines pooled across all three time points at baseline, 1-week, and 2-week post cryptococcal meningitis diagnosis.
| Biomarkers | Combined Correlation | Rate of Change Over Time | ||||
|---|---|---|---|---|---|---|
| N | Rho | p value | N | Rho | p value | |
| Innate immune response | ||||||
| IL-6 | 403 | -0.07 | 0.16 | 160 | 0.151 | 0.06 |
| IL-1β | 403 | 0.029 | 0.57 | 160 | 0.070 | 0.38 |
| IL-8 | 403 | 0.029 | 0.56 | 160 | 0.132 | 0.10 |
| G-CSF | 403 | 0.067 | 0.18 | 160 | 0.086 | 0.28 |
| GM-CSF | 403 | 0.147 | 0.003∗ | 160 | -0.030 | 0.70 |
| MCP-1 | 403 | 0.073 | 0.15 | 160 | 0.111 | 0.16 |
| MIP-1α | 214 | -0.127 | 0.06 | 118 | 0.061 | 0.51 |
| MIP-1β | 403 | 0.10 | 0.05 | 160 | -0.119 | 0.13 |
| CD14 | 312 | 0.095 | 0.09 | 128 | 0.180 | 0.04 |
| CD163 | 312 | -0.051 | 0.37 | 128 | -0.143 | 0.11 |
| Adaptive immune response | ||||||
| IFN-γ | 403 | 0.119 | 0.02 | 160 | 0.120 | 0.13 |
| TNF-α | 403 | 0.102 | 0.04 | 160 | 0.096 | 0.23 |
| IL-12 | 403 | -0.021 | 0.67 | 160 | -0.003 | 0.97 |
| IL-2 | 403 | 0.089 | 0.08 | 160 | -0.057 | 0.48 |
| IL-7 | 403 | 0.036 | 0.47 | 160 | -0.032 | 0.69 |
| IL-10 | 403 | -0.062 | 0.21 | 160 | 0.068 | 0.40 |
| IL-5 | 403 | 0.041 | 0.41 | 160 | 0.059 | 0.46 |
| IL-4 | 403 | 0.082 | 0.10 | 160 | -0.063 | 0.43 |
| IL-13 | 403 | -0.093 | 0.06 | 160 | 0.194 | 0.014 |
| IL-17 | 403 | 0.066 | 0.19 | 160 | -0.082 | 0.30 |
| Hemostasis | ||||||
| VEGF | 307 | 0.051 | 0.37 | 147 | -0.059 | 0.48 |
∗ p value of less than 0.01. Interleukin: IL; interferon: IFN; tumor-necrosis factor: TNF; granulocyte colony-stimulating factor: G-CSF; granulocyte-macrophage colony-stimulating factor: GM-CSF; monocyte chemoattractant protein-1/CCL2: MCP-1; macrophage inflammatory protein: MIP; and vascular endothelial growth factor: VEGF.