Table 2.
Hemodynamic changes in the RDN and SHAM groups.
| RDN group (N = 6) | SHAM group (N = 6) | P, between groups, when parameters were analyzed after procedures | A subgroup of RDN animals with MAP drop: delta in parameters after ablation, median [IQR], N = 5 | P, five RDN cases with MAP drop, comparison of parameters before and after ablation | |||
|---|---|---|---|---|---|---|---|
| Before RDN, mean ± SD | After RDN, mean ± SD | Before sham, mean ± SD | After sham, mean ± SD | ||||
| HR (min−1) | 116.7 ± 15.1 | 118.2 ± 21.8 | 95.8 ± 11.7 | 102.2 ± 19.1 | 0.24 | 3 [-2; 12] | 0.34 |
| sBP (mmHg) | 97 ± 16.5 | 90.8 ± 11.4 | 88.3 ± 7.5 | 93.2 ± 8 | 0.03 | -6 [-14; -6] | 0.04 |
| dBP (mmHg) | 60.3 ± 11.6 | 56 ± 8.2 | 54.5 ± 6.4 | 60.2 ± 6 | 0.05 | -7 [-9; -4] | 0.14 |
| MAP (mmHg) | 72.7 ± 13.2 | 66 ± 9.6 | 65.7 ± 6.4 | 71.2 ± 6.6 | 0.04 | -7 [-10; -6] | 0.04 |
| sPAP (mmHg) | 19.5 ± 4.3 | 18.3 ± 5.2 | 15.7 ± 4 | 15 ± 3.4 | 0.24 | -1 [-1; 0] | 0.27 |
| dPAP (mmHg) | 13 ± 4.4 | 10 ± 3 | 11.8 ± 3.8 | 10.7 ± 2.4 | 0.82 | -2 [-5; -1] | 0.06 |
| mPAP (mmHg) | 15.1 ± 4.1 | 13.3 ± 2.9 | 13 ± 3.9 | 12.2 ± 2.9 | 0.48 | -1 [-4; 0] | 0.11 |
| sRV (mmHg) | 18.5 ± 6.6 | 19.3 ± 5.2 | 13.8 ± 4.3 | 13.3 ± 3.1 | 0.04 | -1 [-3; 3] | 0.89 |
| dRV (mmHg) | 5 ± 2.6 | 4.5 ± 2.6 | 6.5 ± 3.3 | 6 ± 1.3 | 0.48 | 0 [-1; 0] | 0.18 |
| mRV (mmHg) | 9.3 ± 2.8 | 9.3 ± 2.2 | 8.8 ± 3.7 | 8.2 ± 1.7 | 0.31 | -1 [-1; -1] | 0.22 |
| PWP (mmHg) | 4.7 ± 1.8 | 4 ± 1.1 | 5 ± 2.4 | 4.7 ± 1.9 | 0.39 | -1 [-2; 0] | 0.47 |
| RAP (mmHg) | 3.8 ± 2.7 | 2 ± 1.7 | 4.4 ± 2.4 | 3.2 ± 1.6 | 0.24 | -3 [-3; -2] | 0.07 |
| SVR (dyn∗sec∗cm−5) | 1747.7 ± 726.1 | 1544.9 ± 725.8 | 1113.4 ± 520.3 | 1193.1 ± 589.7 | 0.24 | -252.9 [-591.7; 96.0] | 0.22 |
| PVR (dyn∗sec∗cm−5) | 261.9 ± 99.3† | 215.1 ± 65.9 | 136.9 ± 58.5† | 133.7 ± 86.3 | 0.06 | -88.0 [-92.4; -36.5] | 0.03 |
| CO (l/min) | 3.6 ± 1.5 | 3.7 ± 1.2 | 5 ± 1.8 | 5.4 ± 2.3 | 0.24 | 0.2 [-0.3; 0.5] | 0.68 |
HR: heart rate; sBP: systolic blood pressure; dBP: diastolic blood pressure; MAP: mean arterial pressure; sPAP: systolic pulmonary artery pressure; dPAP: diastolic pulmonary artery pressure; mPAP: medium pulmonary artery pressure; sRV: systolic right ventricle pressure; dRV: diastolic right ventricle pressure; mRV: medium right ventricle pressure; PWP: pulmonary wedge pressure; RAP: right atrial pressure; SVR: systemic vascular resistance; PVR: pulmonary vascular resistance; CO: cardiac output. †P = 0.03 in baseline parameters between the groups.