Table 1.
Demographic, clinical, and histopathological parameters of HCC patients according to CLD etiology.
| Characteristics | All etiologies | Viral group (n = 41) | Nonviral group (n = 39) | p value | ||
|---|---|---|---|---|---|---|
| HBV | HCV | Alcohol | Cryptogenic | |||
| Number | 80 (100.0) | 10 (12.5) | 31 (38.8) | 20 (25.5) | 19 (23.7) | NA |
|
| ||||||
| Age (years) | 58.0 (52.0–64.0) | 56.0 (38.8–60.4) | 56.0 (51.0–62.0) | 58.5 (52.0–63.7) | 63.0a (57.0–66.8) | 0.023b |
|
| ||||||
| Gender | ||||||
| F | 20 (25.0) | 1 (10.0) | 12 (38.7)a | 1 (5.0) | 6 (31.6) | 0.021b |
| M | 60 (75.5) | 9 (90.0) | 19 (61.3) | 19 (95.0)a | 13 (68.4) | — |
| MELD | 20 (16–24) | 21(20–28) | 20 (14–26) | 20 (17–23) | 20 (17–22) | 0.760b |
|
| ||||||
| CHILD | ||||||
| A | 29/67 (43.2) | 6/8 (75.0) | 13/25 (52.0) | 5/19 (26.3) | 5/15 (33.3) | 0.205c |
| B | 19/67 (28.4) | 1/8 (12.5) | 8/25 (32.0) | 6/19 (31.6) | 4/15 (26.7) | — |
| C | 19/67 (28.4) | 1/8 (12.5) | 4/25 (16.0) | 8/19 (42.1) | 6/15 (40.0) | — |
| AFP (ng/mL) | 14.7 (5.87–72.4) | 14.1 (3.17–585.2) | 25.1 (8.2–73.6) | 14.2 (5.3–64.3) | 7.4 (4.4–94.3) | 0.421b |
|
| ||||||
| No. of nodules | ||||||
| ≤3 | 58/75 (77.3) | 8/9 (88.9) | 23/30 (76.7) | 16 (80) | 11/16 (68.8) | 0.751c |
| >3 | 17/75 (22.7) | 1/9 (11.1) | 7/30 (23.3) | 4 (20) | 5/16 (31.3) | — |
| Size of biggest nodule (cm) | 2.8 (2.0–3.5) | 2.8 (1.7–5.2) | 2.5 (2.1–3.5) | 2.6 (2.0–3.4) | 3.25 (2.5–5.0) | 0.411b |
|
| ||||||
| Histologic grade | ||||||
| Low | 52/73 (71.2) | 8 (80.0) | 17/28 (60.6) | 12/18 (66.7) | 15/17 (88.2) | 0.221c |
| High | 21/73 (28.7) | 2 (20.0) | 11/28 (39.3) | 6/18 (33.3) | 2/17 (11.8) | — |
|
| ||||||
| MIV | ||||||
| No | 45/71 (63.3) | 9 (90) | 14/27 (51.9) | 11/17 (64.7) | 11/17 (64.7) | 0.166c |
| Yes | 26/71 (36.7) | 1 (10) | 13/27 (48.1) | 6/17 (35.3) | 6/17 (35.3) | — |
Data are expressed as absolute numbers (percentage) and median (interquartile range). Number of patients with the characteristic/number for whom the information was available. HCC, hepatocellular carcinoma; CLD, chronic liver disease; HBV, hepatitis B virus; HCV, hepatitis C virus; NA, not applicable; F, female; M, male; MELD, Model for End-Stage Liver Disease; CHILD, Child-Pugh classification; AFP, alpha-fetoprotein; MIV, microvascular invasion. aStatistically significant difference. bKruskal–Wallis test. cFisher's exact test.