Table 2.

Stability of BAPCs and Their Cleavage by NADPH-Cytochrome P450 Oxidoreductase

compound	percent BAPC hydrolysi s/cl eavage (non-enzymatic) in phosphate buffer (pH 7.4, 48 h)	percent BAPC cleavage by POR (90 min)
22	0.25	NCa
23	0.84	13.5
24	1.59	1.1
25	0.69	3.8
26	4.03	7.6
35	0	NC
36	0	NC
37	0b	14.2
	(24% cyclization of 37 to 35)
38	0.5c	5.6
	(48% cyclization of 38 to 36)
39	0b	17.9
	(46% cyclization of 39 to 35)
40	0c	25.5
	(35% cyclization of 40 to 36)
41	100	100
43	0.35	2.7
44	ND	4.1
45	0.69	25.4

^aNC= no cleavage observed.

^bsignificant cyclization to 35.

^csignificant cyclization to 36.