Table 4. Comparison of SIRT1 and PGC-1α expression in pre and post intervention by the study groups in according to different models.

Gene	Time point	Selenium (n = 50)	Placebo (n = 50)	Mean difference (95% CI)	Cohen's d (95% CI)	p value	Adjusted R2	Adjusted p value‡	Adjusted p value§
SIRT1	Pre	0.863 ± 0.149	0.972 ± 0.285	-	-	0.512*	-	-	-
	Post	1.573 ± 0.111	0.896 ± 0.109	0.67 (0.36–0.98)	0.86 (0.45–1.27)	< 0.001†	0.15	< 0.001	< 0.001
PGC-1α	Pre	1.102 ± 0.866	1.110 ± 0.131	-	-	0.964*	-	-	-
	Post	1.352 ± 0.102	1.141 ± 0.100	0.21 (−0.07–0.49)	0.29 (−0.10–0.68)	0.146†	0.42	0.148	0.149

Data presented as mean ± standard deviation.

PGC-1α, peroxisome proliferator-activated receptor γ coactivator-1α; SIRT1, silent information regulator 1; CI, confidence interval; ANOVA, analysis of variance; ANCOVA, analysis of covariance.

^*Calculated based on independent t-test; ^†Calculated based on ANOVA model; ^‡Adjusted for potential covariate (the baseline value, age) (calculated based on ANOVA/ANCOVA model); ^§Adjusted for potential covariate (the baseline value, colitis groups) (calculated based on ANOVA/ANCOVA model).