Table 2. Change of hematological parameters.

Hematological parameters		SPB-201		Placebo		p value
		No.	Mean ± SD	No.	Mean ± SD
WBC (103/µL)
	Baseline	48	6.05 ± 1.51	48	6.28 ± 1.58	0.4704†
	Week 8	43	6.08 ± 1.13	44	6.49 ± 1.62
	Change from baseline	43	0.08 ± 1.48	44	0.22 ± 1.11	0.5637†
RBC (106/µL)
	Baseline	48	4.96 ± 0.46	48	4.88 ± 0.40	0.3460*
	Week 8	43	4.84 ± 0.49	44	4.81 ± 0.40
	Change from baseline	43	−0.12 ± 0.24	44	−0.06 ± 0.21	0.1729†
Hb (g/dL)
	Baseline	48	15.18 ± 1.35	48	15.06 ± 1.15	0.8173†
	Week 8	43	14.77 ± 1.45	44	14.86 ± 1.13
	Change from baseline	43	−0.41 ± 0.70	44	−0.15 ± 0.61	0.0687*
Hct (%)
	Baseline	48	44.86 ± 3.89	48	44.26 ± 3.13	0.4180†
	Week 8	43	43.62 ± 4.24	44	43.69 ± 3.34
	Change from baseline	43	−1.33 ± 2.11	44	−0.47 ± 1.85	0.0462*
MCV (FL)
	Baseline	48	90.55 ± 4.03	48	90.91 ± 4.58	0.6799*
	Week 8	43	90.34 ± 4.28	44	90.93 ± 4.20
	Change from baseline	43	−0.52 ± 1.99	44	0.02 ± 1.98	0.3287†
Platelet (103/µL)
	Baseline	48	254.50 ± 54.01	48	266.90 ± 56.01	0.2725*
	Week 8	43	238.35 ± 46.65	44	268.73 ± 57.46
	Change from baseline	43	−16.88 ± 29.75	44	1.45 ± 27.54	0.0037*
Segmented neutrophil (%)
	Baseline	48	53.39 ± 8.73	48	52.16 ± 8.30	0.4800*
	Week 8	43	53.09 ± 8.74	44	52.31 ± 8.42
	Change from baseline	43	−0.37 ± 7.26	44	0.87 ± 6.45	0.4018*
Lymphocyte (%)
	Baseline	48	35.78 ± 7.89	48	37.94 ± 7.90	0.1828*
	Week 8	43	36.38 ± 8.48	44	37.67 ± 7.60
	Change from baseline	43	0.71 ± 7.34	44	−0.85 ± 5.62	0.2683*
Monocyte (%)
	Baseline	48	6.96 ± 1.44	48	6.61 ± 1.60	0.2236†
	Week 8	43	6.97 ± 1.91	44	6.44 ± 1.52
	Change from baseline	43	0.04 ± 1.36	44	−0.23 ± 1.12	0.3250*
Eosinophil (%)
	Baseline	48	3.23 ± 2.80	48	2.68 ± 1.66	0.4635†
	Week 8	43	3.36 ± 3.64	44	2.90 ± 2.09
	Change from baseline	43	0.04 ± 1.48	44	0.14 ± 1.53	0.9425†
Basophil (%)
	Baseline	48	0.68 ± 0.29	48	0.63 ± 0.22	0.3472*
	Week 8	43	0.71 ± 0.39	44	0.69 ± 0.29
	Change from baseline	43	0.04 ± 0.29	44	0.05 ± 0.24	0.5714†

WBC, white blood cell; RBC, red blood cell; Hb, hemoglobin; Hct, hematocrit; MCV, mean corpuscular volume

Compared between groups: ^*p value by 2 sample t-test; ^†p value by Wilcoxon rank sum test.