Table 3. Change of hemochemical parameters.

Hemochemical parameters		SPB-201		Placebo		p value
		No.	Mean ± SD	No.	Mean ± SD
Protein (g/dL)
	Baseline	48	7.50 ± 0.43	48	7.50 ± 0.42	1.0000*
	Week 8	43	7.36 ± 0.30	44	7.37 ± 0.39
	Change from baseline	43	−0.15 ± 0.33	44	−0.13 ± 0.27	0.7373*
Albumin (g/dL)
	Baseline	48	4.53 ± 0.25	48	4.53 ± 0.29	0.9057†
	Week 8	43	4.42 ± 0.23	44	4.44 ± 0.26
	Change from baseline	43	−0.12 ± 0.20	44	−0.08 ± 0.19	0.3283†
Total bilirubin (mg/dL)
	Baseline	48	0.91 ± 0.40	48	0.84 ± 0.39	0.2588†
	Week 8	43	0.83 ± 0.40	44	0.80 ± 0.33
	Change from baseline	43	−0.09 ± 0.23	44	−0.05 ± 0.29	0.4853*
ALP (U/L)
	Baseline	48	166.58 ± 93.94	48	148.15 ± 75.77	0.3953†
	Week 8	43	167.79 ± 96.37	44	145.80 ± 73.49
	Change from baseline	43	0.02 ± 20.07	44	−0.70 ± 19.09	0.8953†
Glucose (mg/dL)
	Baseline	48	100.94 ± 13.74	48	105.58 ± 21.27	0.4524†
	Week 8	43	102.91 ± 15.07	44	105.39 ± 15.70
	Change from baseline	43	3.44 ± 14.22	44	1.23 ± 11.80	0.5102†
BUN (mg/dL)
	Baseline	48	14.59 ± 3.81	48	13.88 ± 3.90	0.5048†
	Week 8	43	14.71 ± 3.75	44	13.95 ± 4.48
	Change from baseline	43	0.06 ± 3.76	44	0.10 ± 3.82	0.9524*
Cr (mg/dL)
	Baseline	48	0.86 ± 0.18	48	0.84 ± 0.17	0.5481*
	Week 8	43	0.83 ± 0.16	44	0.82 ± 0.17
	Change from baseline	43	−0.02 ± 0.08	44	−0.01 ± 0.08	0.3678†
UA (mg/dL)
	Baseline	48	6.10 ± 1.75	48	5.98 ± 1.42	0.8575†
	Week 8	43	5.96 ± 1.64	44	6.05 ± 1.36
	Change from baseline	43	−0.14 ± 0.80	44	0.04 ± 0.73	0.1996†
Ca (mg/dL)
	Baseline	48	9.39 ± 0.78	48	9.35 ± 0.39	0.3890†
	Week 8	43	9.29 ± 0.29	44	9.20 ± 0.33
	Change from baseline	43	−0.10 ± 0.81	44	−0.15 ± 0.31	0.5636†
Na (mmol/L)
	Baseline	48	139.52 ± 2.37	48	139.48 ± 1.77	0.9302*
	Week 8	43	139.42 ± 1.88	44	139.32 ± 1.95
	Change from baseline	43	−0.23 ± 2.72	44	−0.31 ± 1.86	0.7693†
K (mmol/L)
	Baseline	48	4.36 ± 0.37	48	4.38 ± 0.33	0.8166*
	Week 8	43	4.24 ± 0.34	44	4.33 ± 0.34
	Change from baseline	43	−0.14 ± 0.38	44	−0.06 ± 0.34	0.2844*
Cl (mmol/L)
	Baseline	48	103.26 ± 2.79	48	103.56 ± 2.33	0.5685*
	Week 8	43	103.63 ± 2.47	44	103.77 ± 2.11
	Change from baseline	43	0.47 ± 2.66	44	0.02 ± 1.95	0.3752*

ALP, alkaline phosphate; BUN, blood urea nitrogen; Cr, creatinine; UA, uric acid; Ca, calcium; Na, sodium; K, potassium; Cl, chloride.

Compared between groups: ^*p value by 2 sample t-test; ^†p value by Wilcoxon rank sum test.