Fig. 6.

MSA (Multiple Sequence Alignment) of the refined spike model with the assorted spike glycoprotein sequences listed in Table 1. The Receptor-Binding Domain (RBD, 319–541) consisted of the Receptor-Binding Motif (RBM, 437–508). 15 RBD residues were implicated in molecular interactions with ACE-2 (red and green). The cysteine residues (dark blue) were involved in disulphide bond interactions. MSA revealed mutation of amino acid residues of SARS-CoV-2 viz. V417K, T446G, P475A, W490F, N493Q, and T501N respectively (green). The other possible mutations within the strains are reported by white within the strains. (Colour, Double-column fitting image).