Table 4.

Functional domain prediction by MOTIF search server.

Whole Spike Glycoprotein
Sr.No.	PfamaID	Pfam	Position	IE-valueb	Descripton
1	PF01601	Corona_S2	686–1270	1.4e-266	Coronavirus S2 glycoprotein
2	PF09408	Spike_rec_bind	330–583	6.6e-75	spike receptor binding domain
3	PF16451	Spike_NTD	262–294	0.0014	spike glycoprotein N-terminal domain
4	PF04513	Baculo_PEP_C	931–989	0.11	Baculovirus polyhedron envelope protein, PEP, C-terminus
5	PF11172	DUF2959	917–1015	0.057	Unknown functional protein
6	PF17192	MukF_M	906–969	0.22	MukF middle domain
7	PF16025	CALM_bind	853–871	0.26	Calcium-dependent calmodulin binding
8	PF16519	TRPM_tetra	934–962	0.21	TRPM tetramerization domain
9	PF00517	GP41	1149–1241	0.26	Retroviral envelope protein
Spike RBD model
10	PF09408	Spike_rec_bind	1–200	2.7e-60	spike receptor binding domain

^aPfam = Protein family.

^bIE-value = Independent E-value.