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. 2020 Sep 25;39(45):6879–6892. doi: 10.1038/s41388-020-01466-x

Fig. 3. BCYRN1 inhibits glioma tumor formation in vivo.

Fig. 3

a Illustration of the tumor transplantation timelines when treated with BCYRN1 overexpression lentivirus. The divergent arrows indicate the different stages. b Expression level of BCYRN1 in U251 cells after transduction with overexpression lentivirus. c The tumor sizes were measured. d Bioluminescence imaging of xenograft tumors in mice was shown. e Stable U251 cells (1 × 107 per mouse, n = 5 each group) were subcutaneously injected into BALB/c nude mice (two groups) to establish subcutaneous xenograft tumors. f The dissected tumors were photographed. g, h The tumor volumes and weights were measured. i, j IHC staining revealed the expression of Ki67, CUEDC2, PTEN, P-AKT, P21 when treated with BCYRN1 overexpression lentivirus. Scale bars, 50 μm. Error bars, S.E.M. from three independent experiments. *P < 0.05; **P < 0.01; ***P < 0.001 by two-tailed Student’s t test.