Table 4.
Hereditary Patterns in 67 Pedigrees of Cluster Headachea
| Pedigree | Affected participants, No./total No. | |
|---|---|---|
| Individuals | Generations | |
| Autosomal dominant | ||
| Bordini et al12 | ||
| 2 | 2/18 | 2/4 |
| 3 | 2/10 | 2/3 |
| El Amrani et al26 | ||
| 1 | 3/14 | 3/4 |
| 5 | 3/19 | 2/4 |
| 9 | 3/12 | 3/3 |
| Kudrow and Kudrow27 | ||
| K118 | 3/4 | 2/2 |
| K119 | 3/9 | 3/4 |
| K120 | 3/7 | 3/3 |
| K121 | 4/7 | 3/3 |
| K122 | 4/6 | 2/2 |
| Sjöstrand et al13 | ||
| 2 | 2/9 | 2/3 |
| 9 | 4/17 | 3/3 |
| Zarrilli et al41 | ||
| A | 2/11 | 2/3 |
| E | 4/12 | 3/3 |
| G | 2/20 | 2/3 |
| Autosomal dominant with incomplete penetrance | ||
| El Amrani et al,26 16 | 3/14 | 2/3 |
| Montagna et al38 | ||
| B | 2/18 | 2/4 |
| E | 4/14 | 3/3 |
| Autosomal dominant or in an X-linked pattern | ||
| El Amrani et al26 | ||
| 2 | 3/17 | 2/3 |
| 4 | 2/8 | 2/3 |
| 6 | 2/16 | 2/3 |
| 7 | 4/11 | 2/4 |
| 8 | 3/10 | 2/3 |
| 12 | 2/14 | 2/3 |
| Kudrow and Kudrow27 | ||
| K100 | 2/9 | 2/3 |
| K101 | 2/7 | 2/2 |
| K103 | 2/5 | 2/3 |
| K104 | 2/6 | 2/3 |
| K105 | 2/7 | 2/3 |
| K106 | 2/9 | 2/3 |
| K110 | 2/11 | 2/3 |
| K111 | 2/10 | 2/3 |
| K112 | 2/7 | 2/3 |
| K113 | 2/11 | 2/3 |
| K114 | 3/10 | 3/4 |
| K115 | 3/8 | 3/3 |
| K116 | 3/7 | 2/3 |
| K117 | 3/7 | 3/3 |
| Sjöstrand et al,13 6 | 2/8 | 2/3 |
| Autosomal dominant or X-linked with incomplete penetrance | ||
| Haan et al55 | 3/26 | 2/5 |
| Montagna et al,38 A | 3/18 | 2/5 |
| Sjöstrand et al13 | ||
| 1 | 3/12 | 2/3 |
| 5 | 3/13 | 2/3 |
| Zarrilli et al,41 B | 3/22 | 2/4 |
| Autosomal dominant, X-linked, or polygenic | ||
| El Amrani et al,26 3 | 3/12 | 2/3 |
| Autosomal dominant or X-linked with incomplete penetrance or polygenic | ||
| Kudrow and Kudrow,27 K123 | 5/22 | 3/4 |
| Autosomal dominant with incomplete penetrance or autosomal recessive | ||
| El Amrani et al,26 20 | 3/21 | 1/4 |
| Zarrilli et al,41 F | 3/22 | 1/3 |
| Autosomal recessive | ||
| Bordini et al,12 1 | 2/21 | 1/3 |
| El Amrani et al26 | ||
| 10 | 2/11 | 1/3 |
| 11 | 2/9 | 1/3 |
| 13 | 2/20 | 1/4 |
| 14 | 2/13 | 1/3 |
| 15 | 2/8 | 1/2 |
| 17 | 2/14 | 1/3 |
| 18 | 2/15 | 1/3 |
| 19 | 2/15 | 1/3 |
| Kudrow and Kudrow27 | ||
| K102 | 2/7 | 1/3 |
| K107 | 2/4 | 1/2 |
| K108 | 2/15 | 1/3 |
| K109 | 2/5 | 1/2 |
| Montagna et al38 | ||
| C | 2/11 | 1/3 |
| D | 2/7 | 1/3 |
| Sjöstrand et al,13 3 | 2/10 | 1/3 |
| Zarrilli et al41 | ||
| C | 2/24 | 1/4 |
| D | 3/18 | 1/3 |
| Autosomal recessive or polygenic | ||
| De Simone et al42 | 8/151 | 2/4 |
a
Results were analyzed for the most likely inheritance pattern, although it should be noted that incomplete penetrance and multifactorial and/or polygenic inheritance patterns cannot be ruled out. In this analysis, we ignored the diagnosis of atypical cluster headache; relatives identified by the original studies as having atypical cluster headache were considered to be unaffected relatives. Numbers in the leftmost column refer to the figure numbers (for Bordini et al12) or pedigree number (for El Amrani et al,26 Kudrow and Kudrow,27 and Sjöstrand et al13). Letters in the leftmost column refer to pedigree letters (for Zarrilli et al41 and Montagna et al38)