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. 2020 May 6;12(2):303–315. doi: 10.1007/s12975-020-00819-8

Fig. 6.

Fig. 6

Degree of infarct size in TAK-063-treated mice. a Top panel shows Nissl-stained brain tissue section from representative stroke + 3.0 mg/kg group at 10 weeks post-stroke. The arrow indicates the core of the infarct. The lower panels quantifies the degree of stroke. The Y-axis indicates the normalized ratio of the ipsilateral stroked hemisphere over the contralateral non-stroked hemisphere. Data shown are measurements at − 0.22 to − 0.82 mm from Bregma. Stroke leads to a loss of tissue volume in the hemisphere ipsilateral to the stroke. Lower values indicate loss of tissue volume. Data show that there was no effect between the treatment groups; however, b stroke + 3.0 mg/kg and stroke + vehicle group shows a significant difference compared to sham + vehicle; *P = 0. 0146; *P = 0.0053; n = 8–10 per group. c The combined stroke groups versus the combined sham control groups (n = 18 and 32, *P = 0.001). All P values corrected for multiple comparisons. Error bars represent mean ± SEM. Scale bar = 50 μm and applies to all photomicrographs