Therapeutic Effects of Intraperitoneal Administration of AmNA-Modified anti-SYT13 ASOs
(A) IVIS analysis of representative mice in each treatment group, 3 weeks after engraftment with MKN1 cells. (B) Macroscopic appearance of peritoneal nodules, 6 weeks after implantation of MKN1 cells, and comparison of the total volume of peritoneal nodules in each treatment group. (C) The macroscopic appearance of satellite mice 8 weeks after implantation of NUGC4 cells. (D) Survival of mice treated with intraperitoneal administration of vehicle, ASO-NEG, hSYT13-4378, or hSYT13-4733. Error bars indicate the standard deviation.