Table 4.

Conditional Indirect Effects of Childhood Adversity (CA) and Genetic Risk Score for Obesity (GRSO) on Health Outcomes (Chronic Illness; Cardiometabolic Risk; DNAm PhenoAge) via Residualized Change in Body Mass Index (ΔBMI).

Paths	Effect	95% CI	p
Low GRSO (−1sd)
CA → ΔBMI → Chronic Illness by Low GRSO	.001	[−.002,.005]	.587
CA → ΔBMI → CMR by Low GRSO	.016	[−.021, .054]	.410
CA → ΔBMI → DNAm PhenoAge by Low GRSO	.012	[−.012, .052]	.471
Low C4 (−1sd)
GRSO → ΔBMI → Chronic Illness by Low CA	.002	[−.008,.017]	.766
GRSO → ΔBMI → CMR by Low CA	.029	[−.099,.190]	.707
GRSO → ΔBMI → DNAm PhenoAge by Low CA	.021	[−.075,.174]	.753
High GRSO (+1sd)
CA → ΔBMI → Chronic Illness by High GRSO	.008**	[.003,.015]	.008
CA → ΔBMI → CMR by High GRSO	.092**	[.042,.140]	.000
CA → ΔBMI → DNAm PhenoAge by High GRSO	.067*	[.025,.158]	.047
High CA (+1sd)
GRSO → ΔBMI → Chronic Illness by High CA	.022**	[.009,.043]	.011
GRSO → ΔBMI → CMR by High CA	.266**	[.144,.375]	.000
GRSO → ΔBMI → DNAm PhenoAge by High CA	.193**	[.075,.374]	.011

Note:

^**p ≤ .01;

^*p ≤ .05 (two-tailed tests), n = 412. Values are unstandardized parameter estimates and confidence intervals. CA = Childhood Adversity; ΔBMI = Change in body mass index; CMR = Cardiometabolic Risk; GRSO = Genetic risk score for obesity