Table 2.
Flash glucose monitoring parameters of glucose variability in patients administered tofogliflozin or ipragliflozin
| Tofogliflozin | Ipragliflozin | p-value | |
|---|---|---|---|
| Time in target glucose range (target range 70–180 mg/dl) (%) | 86.1 ± 13.7 | 74.8 ± 13.7 | < 0.001* |
| Time above target glucose range (above target level > 180 mg/dl) (%) | 11.8 ± 13.8 | 16.5 ± 14.4 | 0.044* |
| 24-h SD (mg/dl) | 34.4 ± 11.1 | 42.3 ± 12.6 | < 0.001* |
| 24-h M value (target glucose level 100 mg/dl) | 6.3 ± 5.1 | 9.3 ± 5.5 | 0.061 |
| MAGE (mg/dl) | 82.4 ± 26.0 | 99.4 ± 31.7 | < 0.001* |
| MODD (mg/dl) | 23.7 ± 8.9 | 22.1 ± 6.6 | 0.486 |
| 24-h mean glucose level (mg/dl) | 124.9 ± 22.9 | 128.3 ± 24.0 | 0.382 |
| 0000–0600-h mean glucose level (mg/dl) | 96.6 ± 22.5 | 88.3 ± 20.1 | 0.021* |
| Preprandial glucose level at breakfast (mg/dl) | 94.0 ± 20.9 | 88.0 ± 20.0 | 0.075 |
| Preprandial glucose level at lunch (mg/dl) | 124.9 ± 37.2 | 130.5 ± 31.7 | 0.337 |
| Preprandial glucose level at supper (mg/dl) | 113.3 ± 42.7 | 109.3 ± 32.2 | 0.527 |
| Glucose level 2 h after breakfast (mg/dl) | 140.8 ± 31.0 | 155.8 ± 44.2 | 0.020* |
| Glucose level 2 h after lunch (mg/dl) | 159.7 ± 38.3 | 174.3 ± 45.5 | 0.040* |
| Glucose level 2 h after supper (mg/dl) | 159.8 ± 48.9 | 181.2 ± 54.2 | 0.014* |
| Time below target glucose range (below target level < 70 mg/dl) (%) | 2.1 ± 4.4 | 8.7 ± 11.7 | < 0.001* |
| Time below target glucose range (below target level < 54 mg/dl) (%) | 0.1 ± 0.5 | 1.0 ± 2.3 | 0.001* |
| Nocturnal time below target glucose (below target level < 70 mg/dl) (%) | 0.9 ± 2.6 | 5.6 ± 7.7 | < 0.001* |
| 24-h AUC (mg/dl h) | 2988.1 ± 547.6 | 3070.3 ± 573.5 | 0.381 |
| 0800–2200 h AUC (mg/dl h) | 1964.3 ± 410.6 | 2144.6 ± 448.2 | 0.153 |
| 2200–0800 h AUC (mg/dl h) | 1068.0 ± 215.0 | 994.8 ± 212.5 | 0.242 |
| 24-h UGE (g) | 55.7 ± 22.2 | 47.7 ± 13.7 | 0.138 |
| 0800–2200 h UGE (g) | 46.9 ± 20.4 | 32.6 ± 12.0 | 0.005* |
| 2200–0800 h UGE (g) | 8.8 ± 3.0 | 15.1 ± 3.5 | < 0.001* |
| 0600 h serum albumin (g/dl) | 3.8 ± 0.4 | 3.8 ± 0.4 | 0.603 |
| 2100 h serum albumin (g/dl) | 4.1 ± 0.4 | 4.1 ± 0.5 | 0.678 |
Data are presented as mean ± SD
SD standard deviation of glucose level, MAGE mean amplitude of glycemic excursion, MODD mean of daily difference, AUC area under glucose curve, UGE urinary glucose excretion
*Data were compared using Student’s t-test