Table 2.
Clinical Variables Across the Four Treatments Within the Stepped Care Treatment Group.
| Post-treatment | 6-month follow-up | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BWL+Pla | BWL+Med | CBT+Pla | CBT+Med | BWL+Pla | BWL+Med | CBT+Pla | CBT+Med | |||||||||
| Variable | M | SD | M | SD | M | SD | M | SD | M | SD | M | SD | M | SD | M | SD |
| Binge episodes/month (EDE) | 1.7 | 3.7 | 1.0 | 2.5 | 6.2 | 9.6 | 0.2 | 0.4 | 2.2 | 5.9 | 3.3 | 5.7 | 9.9 | 11.4 | 1.9 | 3.4 |
| EDE Global Score | 1.8 | 0.9 | 1.7 | 0.6 | 1.8 | 1.0 | 1.6 | 0.9 | 1.8 | 1.0 | 1.6 | 0.8 | 2.1 | 1.0 | 1.4 | 0.8 |
| Depression (BDI) | 7.9 | 6.2 | 7.5 | 5.7 | 15.1 | 13.4 | 7.4 | 4.9 | 8.4 | 6.2 | 7.0 | 6.4 | 14.1 | 10.5 | 6.9 | 5.1 |
| Body mass index | 37.1 | 5.5 | 34.9 | 5.5 | 40.6 | 5.6 | 36.3 | 5.0 | 37.9 | 7.0 | 35.0 | 6.6 | 40.6 | 5.8 | 37.3 | 5.4 |
| Weight | 230.8 | 50.0 | 215.2 | 38.5 | 257.5 | 49.5 | 233.7 | 40.3 | 234.5 | 54.9 | 219.8 | 49.1 | 260.8 | 49.5 | 240.0 | 41.2 |
| % Wt Loss from Base | −6.1 | 5.9 | −8.6 | 7.0 | −0.5 | 5.7 | −4.6 | 8.4 | −5.3 | 9.2 | −8.2 | 10.2 | −0.3 | 5.0 | −2.9 | 12.1 |
| % Wt Loss from Post | -- | -- | -- | -- | -- | -- | -- | -- | 0.1 | 6.5 | 1.3 | 6.9 | 0.3 | 2.8 | 1.8 | 5.7 |
| Waist Circumference | 43.6 | 5.9 | 41.9 | 4.8 | 47.4 | 6.5 | 43.4 | 5.4 | 44.2 | 6.3 | 42.3 | 6.0 | 47.4 | 6.7 | 44.3 | 5.0 |
| 12-month follow-up | ||||||||
|---|---|---|---|---|---|---|---|---|
| BWL+Pla | BWL+Med | CBT+Pla | CBT+Med | |||||
| Variable | M | SD | M | SD | M | SD | M | SD |
| Binge episodes/month (EDE) | 2.2 | 5.0 | 2.7 | 5.5 | 4.3 | 6.4 | 0.6 | 1.1 |
| EDE Global Score | 1.6 | 1.0 | 1.6 | 0.7 | 2.0 | 0.9 | 1.5 | 1.0 |
| Depression (BDI) | 7.2 | 6.4 | 6.3 | 5.5 | 16.5 | 13.3 | 6.3 | 6.5 |
| Body mass index | 38.1 | 7.3 | 34.6 | 6.5 | 40.8 | 5.9 | 37.1 | 5.3 |
| Weight | 236.5 | 56.4 | 218.3 | 47.2 | 261.9 | 48.2 | 233.9 | 43.8 |
| % Wt Loss from Base | −6.3 | 9.8 | −7.6 | 10.6 | 0.2 | 6.0 | −2.3 | 12.7 |
| % Wt Loss from Post | −0.1 | 8.4 | 2.6 | 9.3 | 0.9 | 4.2 | 2.9 | 7.5 |
| Waist Circumference | 44.1 | 6.3 | 42.6 | 6.0 | 47.9 | 6.2 | 43.8 | 5.3 |
Note: M = mean. SD = standard deviation. EDE = Eating Disorder Examination. BDI = Beck Depression Inventory; Wt = Weight Within Stepped-care, the following specific treatment cells were created by the stratified randomization: BWL+Pla (N=46), BWL+Med (N=47; of these, N=22 with sibutramine and N=25 with orlistat), CBTgsh+Pla (N=25), and CBTgsh+Med (N=24; of these, N=16 with sibutramine and N=8 with orlistat).