Skip to main content
. Author manuscript; available in PMC: 2021 Nov 1.
Published in final edited form as: Expert Opin Ther Targets. 2020 Oct 5;24(11):1065–1078. doi: 10.1080/14728222.2020.1826929

Fig. 3. Targeting TBK1 in the Tumor Microenvironment.

Fig. 3.

Tumor intrinsic TBK1 signaling in the setting of innate immune response, inflammation, and oncogenesis have been described. Subsequent roles for TBK1 have been established for innate immune signaling (e.g. IRF3/IFN type 1), autophagy/mitophagy, cell cycle, cell growth/metabolism, and cell death, with some evidence of crosstalk between these pathways. Tumor extrinsic TBK1 signaling has been suggested with potential roles for dendritic cells, cytotoxic T lymphocytes, and macrophages.