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. Author manuscript; available in PMC: 2021 Mar 14.
Published in final edited form as: Nat Struct Mol Biol. 2020 Sep 14;27(11):1086–1093. doi: 10.1038/s41594-020-0501-x

Extended Data Fig. 5. Formation of the dimer-of-dimer interface.

Extended Data Fig. 5

a–b, Structural comparison of DUOX1 and DUOXA1 in heterodimeric and dimer-of-dimer states. c, Interaction between DUOX1 and DUOXA1. Left: interactions between DUOX1 and the N-terminal loop and glycan chain linked to N109 of DUOXA1. Right: cryo-EM density and cartoon of the glycan chain on N109. d, Interactions between transmembrane domains of DUOX1 and DUOXA1 mediated by a lipid molecule. Left: interaction details. Right: density of the lipid molecule. e, PHD-PHD interactions in the dimer-of-dimer configuration. Left: interactions between PHDs of DUOX1. Right: comparison between MPO dimers and PHD dimers of DUOX1.