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. Author manuscript; available in PMC: 2021 Mar 14.
Published in final edited form as: Nat Struct Mol Biol. 2020 Sep 14;27(11):1086–1093. doi: 10.1038/s41594-020-0501-x

Extended Data Fig. 2. Structure of the PHD of DUOX1.

Extended Data Fig. 2

a, Superimposition between LPO and PHD of DUOX1. LPO and DUOX1 are colored in grey and blue, respectively. b, Putative heme-binding site. The possible heme-binding pocket indicated by a red oval. Positions of Ser326 and Ser108 (colored in brown) are where the heme-coordinating histidines are located. c, The putative calcium-binding site and surrounding residues. Calcium is indicated by a green sphere. d, A potential ion binding site and surrounding residues. Cryo-EM density is contoured by grey meshes.