Table 2.
Nucleomodulins from bacteria either known or suspiciously involved in induction of tumor.
| Sr. No | Name of nucleomodulins | Bacteria | Function related to carcinogenesis | Type of cancer |
|---|---|---|---|---|
| 1 | VirE3 | Agrobacterium | Transcription induction [27] | Plant Tumor |
| VirF | Agrobacterium tumefaciens | T-DNA translocation for tumor formation | Plant Tumor | |
| 2 | HsvG | Pantoea agglomerans | DNA binding protein, transcriptional activator [87] | Plant Tumor |
| 3 | HsvB | |||
| 4 | SET Domain protein (NUE) | Chlamydia trachomatis | Chromatin modification [65] | Cervical cancer |
| 5 | cpnSET | Chlamydophila pneumoniae | Chromatin modification [59] | Lung cancer |
| 6 | Colibactin | E. coli | DNA damage [83] | Colorectal cancer |
| 7 | Cytolethal distending toxin (CDT) | E. coli | DNA damage, cell cycle arrest [39] | Colorectal cancer |
| 8 | Cif | E. coli | Migrates to host cell nucleus and affects NEDD8 [41] | Colorectal cancer |
| 9 | HP0425 | H. pylori | Translocates to nucleus DNase I-like enzymatic activity [47] | Gastric cancer |
| 10 | HP0059 | H. pylori | Translocates to nucleus DNase I-like enzymatic activity [48] | Gastric cancer |
| 11 | SspH1 | Salmonella enterica serovar Typhimurium | Translocates to nucleus and inhibits NF-kB dependent genes [31] | Hepatobiliary cancer |
| 12 | Rv3423.1 | Mycobacterium tuberculosis | A 8 Kda proteins acetylating histone H3 at the K9/K14 positions [40]. | Lung cancer |