Table 3.

In silico ADME profiling of the compounds

Compounds	Mol. weight	CNS	donorHB	accptHB	QPlogPo/w	QPlogBB	Percent human oral absorption	Rule of five violation	Rule of three violation
C1	192.17	− 1	2	4	0.341	− 0.977	70.84	0	0
C3	320.35	0	0	7	2.276	− 0.291	96.85	0	0
C4	276.24	− 1	0	7.5	0.446	− 0.927	75.22	0	0
C5	220.22	0	0	4.95	1.268	− 0.217	93.6	0	0
C6	340.33	− 1	0	7.5	1.642	− 0.82	84.31	0	0
C7	292.30	0	0	7	1.675	− 0.305	91.63	0	0
C8	292.28	− 2	2	6	1.297	− 1.871	70.27	0	0
C9	332.35	− 2	0	7.5	1.996	− 1.141	86.42	0	0
C10	276.24	− 1	0	7.5	0.38	− 0.969	74.13	0	0
C11	275.26	− 1	1	7.5	0.817	− 0.971	76.92	0	0
C12	236.11	− 2	3	6	− 0.127	− 1.758	43.26	0	1
C13	220.18	− 2	1	4.25	0.891	− 1.321	56.34	0	1
C14	262.21	− 2	1	7	0.648	− 1.321	56.99	0	0
C15	292.30	0	0	7	1.005	− 0.62	82.47	0	0

Mol. Weight molecular weight, donorHB hydrogen bond donor, accptHB hydrogen bond acceptor, BBB blood brain barrier, PSA polar surface area