Table 2.
Relationship of retinal photographic and OCT-A microvascular metrics with NTG.
| Retinal microvascular metrics | Univariable | Multivariable | |||
|---|---|---|---|---|---|
| NTG, OR (95% CI) | P value | NTG, OR (95% CI) | P value | ||
| Photographic vascular metrics | |||||
| CRAE | Per SD decrease | 1.63 (1.17–2.28) | 0.004 | 0.86 (0.49–1.53) | 0.612 |
| CRVE | Per SD decrease | 1.70 (1.22–2.38) | 0.002 | 1.47 (0.85–2.56) | 0.168 |
| Arteriolar Df | Per SD decrease | 1.21 (0.89–1.67) | 0.228 | 0.95 (0.62–1.44) | 0.799 |
| Venular Df | Per SD decrease | 1.09 (0.79–1.47) | 0.628 | 1.04 (0.70–1.53) | 0.851 |
| Arteriolar tortuosity | Per SD decrease | 1.41 (1.03–1.94) | 0.032 | 1.71 (1.15–2.52) | 0.007 |
| Venular tortuosity | Per SD decrease | 1.25 (0.92–1.71) | 0.154 | 1.73 (1.15–2.59) | 0.008 |
| Arteriolar branching angle | Per SD decrease | 1.73 (1.22–2.46) | 0.002 | 1.52 (1.01–2.30) | 0.046 |
| Venular branching angle | Per SD decrease | 1.37 (1.00–1.89) | 0.054 | 1.39 (0.96–2.01) | 0.083 |
| OCT-A capillary metrics | |||||
| cpVD | Per SD decrease | 2.27 (1.53–3.37) | < 0.001 | 2.77 (1.64–4.69) | < 0.001 |
| cpFD | Per SD decrease | 5.14 (2.88–9.17) | < 0.001 | 8.80 (3.93–19.70) | < 0.001 |
CI confidence interval; CRAE central retinal arteriolar equivalent; CRVE central retinal venular equivalent; cpVD circumpapillary vessel density; cpFD circumpapillary fractal dimension; Df fractal dimension; NTG normal tension glaucoma; OR odds ratio; SD standard deviation.
Multivariable model adjusted for age, sex, axial length, systolic blood pressure, fellow caliber (for CRAE and CRVE) and OCT-A image quality score (for OCT-A capillary metrics).