Table 3.
Relationship of retinal photographic and OCT-A microvascular metrics with average RNFL thickness.
| Retinal microvascular metrics | Univariable | Multivariable | |||
|---|---|---|---|---|---|
| Average RNFL thickness, m (95% CI) | P value | Average RNFL thickness, μm (95% CI) | P value | ||
| Photographic vascular metrics | |||||
| CRAE | Per SD decrease | − 4.81 (− 6.98 to − 2.65) | < 0.001 | − 0.44 (− 3.68 to 2.80) | 0.788 |
| CRVE | Per SD decrease | − 5.33 (− 7.47 to − 3.19) | < 0.001 | − 3.22 (− 6.29 to − 0.14) | 0.04 |
| Arteriolar Df | Per SD decrease | − 1.90 (− 4.17 to 0.37) | 0.1 | 0.31 (− 2.11 to 2.73) | 0.8 |
| Venular Df | Per SD decrease | − 1.47 (− 3.74 to 0.81) | 0.206 | − 0.82 (− 3.06 to 1.41) | 0.468 |
| Arteriolar tortuosity | Per SD decrease | − 0.90 (− 3.19 to 1.38) | 0.436 | − 1.02 (− 3.10 to 1.06) | 0.333 |
| Venular tortuosity | Per SD decrease | 0.83 (− 1.46 to 3.11) | 0.476 | − 0.01 (− 2.11 to 2.10) | 0.995 |
| Arteriolar branching angle | Per SD decrease | − 4.48 (− 6.66 to − 2.30) | < 0.001 | − 2.78 (− 4.90 to − 0.65) | 0.011 |
| Venular branching angle | Per SD decrease | − 2.89 (− 5.14 to − 0.65) | 0.012 | − 2.69 (− 4.72 to − 0.66) | 0.01 |
| OCT-A capillary metrics | |||||
| cpVD | Per SD decrease | − 5.43 (− 7.56 to − 3.30) | < 0.001 | − 4.95 (− 7.05 to − 2.85) | < 0.001 |
| cpFD | Per SD decrease | − 6.08 (− 8.17 to − 3.99) | < 0.001 | − 5.52 (− 7.51 to − 3.54) | < 0.001 |
CI confidence interval; CRAE central retinal arteriolar equivalent; CRVE central retinal venular equivalent; cpVD circumpapillary vessel density; cpFD circumpapillary fractal dimension; Df fractal dimension; RNFL retinal nerve fiber layer; SD standard deviation.
Multivariable model adjusted for age, sex, axial length, systolic blood pressure, fellow caliber (for CRAE and CRVE), OCT signal strength and OCT-A image quality score (for OCT-A capillary metrics).