Table 2.
Pharmacogenetic association between SNPs of genes regulating the CRF system and response to antidepressant treatment.
| Responders | Non-responders | Statistics | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Gene | SNPs | Allele | N | % | N | % | Chi² | d.f. | p |
| NR3C1 | rs33388 | A | 1123 | 51.2 | 1510 | 52.1 | 0.41 | 1 | 0.520 |
| rs4912905 | G | 1640 | 75.5 | 2265 | 77.6 | 2.96 | 1 | 0.085 | |
| rs2963155 | A | 1756 | 78.5 | 2266 | 76.6 | 2.71 | 1 | 0.100 | |
| rs41423247 | G | 1433 | 65.7 | 1900 | 65.4 | 0.68 | 1 | 0.794 | |
| rs6189 | G | 2150 | 97.8 | 2907 | 98.0 | 0.24 | 1 | 0.627 | |
| rs4607376 | G | 1170 | 53.4 | 1493 | 50.7 | 3.57 | 1 | 0.059 | |
| rs12656106 | G | 1188 | 54.9 | 1579 | 54.5 | 0.07 | 1 | 0.791 | |
| FKBP5 | rs3800373 | T | 1488 | 70.1 | 2022 | 71.3 | 0.98 | 1 | 0.322 |
| rs7757037 | G | 1187 | 54.0 | 1549 | 52.5 | 1.01 | 1 | 0.316 | |
| rs737054 | C | 1610 | 72.3 | 2111 | 71.9 | 0.14 | 1 | 0.706 | |
| rs1360780 | C | 1505 | 68.6 | 2040 | 69.6 | 0.57 | 1 | 0.452 | |
| rs9470080 | C | 1464 | 67.1 | 1970 | 67.8 | 0.28 | 1 | 0.600 | |
| rs6902321 | T | 1567 | 68.8 | 2093 | 68.4 | 0.12 | 1 | 0.726 | |
| CRHR1 | rs878886 | C | 1710 | 78.2 | 2153 | 73.9 | 12.39 | 1 | <0.001 |
| rs16940665 | T | 1106 | 79.5 | 1180 | 74.2 | 11.39 | 1 | <0.001 | |
| AVPR1B | rs28632197 | G | 1885 | 88.7 | 2572 | 89.5 | 0.70 | 1 | 0.402 |
Significant p values are in bold.