Table 3.

Logistic regression of socio and clinical traits and their potential role as intermediate variables with CRHR1 SNP rs878886 in predictor for treatment response.

Covariable	Association with treatment response			Association with CRHR1 SNP rs878886			Interaction with CRHR1 to predict TTT response
	Wald	p	OR	Chi²	p	OR	Chi²	p	OR
Gender: woman	1.19	0.28	n.a.a	11.56	0.001	0.75 (0.63–0.88)	1.13	0.29	n.a.
Age	21.73	<0.001	1.02(1.01–1.03)	3.33	0.068	0.65 (0.41–1.00)	8.13	0.004	0.99 (0.98–0.99)
Adoption	0.97	0.33	n.a.	12.32	<0.001	0.80 (0.69–90)	1.15	0.28	n.a.
Familial status: not alone	2.06	0.15	n.a.	1.06	0.30	n.a.	0.01	0.98	n.a.
School level over 12 years: low	9.43	0.002	1.55 (1.17–2.05)	7.56	0.006	0.71(0.56–0.91)	0.03	0.87	n.a.
Worker: yes	9.13	0.003	0.59 (0.42–0.83)	3.55	0.06	0.72 (0.51–1.01)	2.32	0.13	n.a.
First MDE	26.71	<0.001	0.54 (0.43–0.68)	13.46	<0.001	0.69 (0.56–0.84)	3.97	0.046	1.31 (1.00–1.71)
Number of previous MDE	0.71	0.40	n.a.	6.30	0.012	0.69 (0.51–0.91)	0.04	0.85	n.a.
Age at first MDE	4.74	0.029	1.01 (1.00–1.03)	0.01	0.94	n.a.	1.34	0.25	n.a.
Lifetime being depressed	0.36	0.55	n.a.	6.77	0.009	0.64 (0.46–0.90)	0.60	0.44	n.a.
Previous SA	0.23	0.63	n.a.	15.95	<0.001	0.75 (0.65–0.87)	4.56	0.03	1.60 (1.04–2.45)
Number of previous SA	1.28	0.26	n.a.	0.19	0.67	n.a.	0.02	0.88	n.a.
Interval V1–V2 (days)	6.27	0.01	0.99 (0.98–0.99)	0.16	0.69	n.a.	2.28	0.13	n.a.
V1-HAD-Anxiety	41.55	<0.001	0.89 (0.86–0.93)	1.45	0.23	n.a.	0.20	0.65	n.a.
V1-HAD-Depression	81.68	<0.001	0.86 (0.83–0.89)	1.20	0.27	n.a.	0.10	0.75	n.a.
V1-HAD-Total	89.07	<0.001	0.90 (0.88–0.92)	1.99	0.16	n.a.	0.68	0.41	n.a.

^aNot applicable.

Significant p values are in bold.