Table 2.
Urine biomarker course over 48 h after hospital admission.
| Biomarker | Day | Moderate PCR (Range) | Severe PCR (Range) | p-value |
|---|---|---|---|---|
| Nephrin [ng/mL] | Adm (n = 26) | 25.06 (9.85; 475.62) | 172.70 (95.49; 2,571.03) | 0.0002 |
| 24 h (n = 24) | 14.30 (7.49; 440.76) | 109.64 (14.43; 1,162.99) | 0.007 | |
| 48 h (n = 21) | 12.59 (4.50; 119.16) | 52.14 (10.73; 2,874.48) | 0.035 | |
| IgG [mg/L] | Adm (n = 26) | 34.10 (3.40; 434.00) | 619.00 (162.00; 3,620.00) | < 0.0001 |
| 24 h (n = 24) | 13.00 (3.70; 265.00) | 337.50 (5.00; 2,090.00) | 0.001 | |
| 48 h (n = 21) | 4.30 (3.70; 103.00) | 80.10 (7.10; 2,760.00) | 0.001 | |
| α1-MG [mg/L] | Adm (n = 26) | 10.00 (5.80; 35.10) | 26.70 (6.20; 127.00) | 0.027 |
| 24 h (n = 24) | 9.15 (5.40; 54.80) | 17.90 (8.60; 76.80) | 0.094 | |
| 48 h (n = 21) | 8.90 (5.40; 46.00) | 18.00 (6.70; 153.00) | 0.020 | |
| ACR [mg/gCr] | Adm (n = 26) | 319.94 (12.23; 1,048.01) | 4117.32 (1,772.65; 29,759.18) | < 0.0001 |
| 24 h (n = 24) | 100.39 (13.81; 634.56) | 2113.47 (28.23; 21,126.05) | < 0.0001 | |
| 48 h (n = 25) | 61.92 (11.55; 124.74) | 335.30 (26.57; 20,803.10) | 0.001 | |
| PCR [mg/gCr] | Adm (n = 26) | 497.90 (30.59; 1,982.69) | 8,392,95 (2,987.55; 50,219.72) | < 0.0001 |
| 24 h (n = 24) | 189.53 (51.78; 1,179.63) | 4,133.69 (143.27; 33,462.55) | < 0.0001 | |
| 48 h (n = 25) | 102.31 (40.41; 308.82) | 689.94 (114.10; 34,510.80) | < 0.0001 |
Adm = day of admission, ACR = albumin-to-creatinine ratio, α1-MG = α1-microglobulin, gCr = gram creatinine, IgG = immunoglobulin G, PCR = protein-to-creatinine ratio.
Bold values are statistically significant for p < 0.05.