Table 4.
Spearman’s correlation of urinary nephrin levels on admission with parameters of hantavirus disease activity.
| Parameters | Nephrin [ng/mL] on admission | ||
|---|---|---|---|
| r | 95%-CI | p-value | |
| Dpo [days] | − 0.44 | − 0.71 to − 0.05 | 0.026 |
| Los [days] | 0.53 | 0.17 to 0.77 | 0.005 |
| Urine parameters | |||
| PCR [mg/gCr] | |||
| Adm (n = 26) | 0.77 | 0.54 to 0.90 | < 0.0001 |
| 24 h (n = 24) | 0.79 | 0.56 to 0.91 | < 0.0001 |
| 48 h (n = 25) | 0.80 | 0.59 to 0.91 | < 0.0001 |
| Max (n = 26) | 0.75 | 0.50 to 0.88 | < 0.0001 |
| ACR [mg/gCr] | |||
| Adm (n = 26) | 0.77 | 0.54 to 0.90 | < 0.0001 |
| 24 h (n = 24) | 0.74 | 0.47 to 0.88 | < 0.0001 |
| 48 h (n = 25) | 0.71 | 0.42 to 0.87 | 0.0001 |
| Max (n = 26) | 0.75 | 0.50 to 0.88 | < 0.0001 |
| IgG [mg/L] | |||
| Adm (n = 26) | 0.83 | 0.64 to 0.92 | < 0.0001 |
| 24 h (n = 24) | 0.77 | 0.53 to 0.90 | < 0.0001 |
| 48 h (n = 21) | 0.84 | 0.62 to 0.93 | < 0.0001 |
| α1-MG [mg/L] | |||
| Adm (n = 26) | 0.69 | 0.40 to 0.85 | 0.0001 |
| 24 h (n = 24) | 0.60 | 0.25 to 0.81 | 0.002 |
| 48 h (n = 21) | 0.78 | 0.51 to 0.91 | < 0.0001 |
| Blood parameters | |||
| SCr [mg/dL] | |||
| Adm (n = 26) | 0.38 | − 0.02 to 0.68 | 0.055 |
| 24 h (n = 26) | 0.69 | 0.40 to 0.85 | < 0.0001 |
| 48 h (n = 24) | 0.76 | 0.50 to 0.89 | < 0.0001 |
| Max (n = 26) | 0.70 | 0.42 to 0.86 | < 0.0001 |
| Platelets [G/L] | |||
| Adm (n = 26) | − 0.67 | − 0.84 to − 0.37 | 0.0002 |
| 24 h (n = 25) | − 0.67 | − 0.84 to − 0.36 | 0.0003 |
| 48 h (n = 24) | − 0.64 | − 0.84 to − 0.31 | 0.001 |
| Min (n = 26) | − 0.51 | − 0.75 to − 0.14 | 0.008 |
| Hemoglobin [g/dL] | |||
| Adm (n = 26) | 0.23 | − 0.19 to 0.58 | 0.259 |
| 24 h (n = 25) | 0.15 | − 0.28 to 0.52 | 0.480 |
| 48 h (n = 24) | − 0.06 | − 0.46 to 0.36 | 0.779 |
| Min (n = 26) | − 0.14 | − 0.51 to 0.28 | 0.512 |
| Leucocytes [G/L] | |||
| Adm (n = 26) | − 0.01 | − 0.41 to 0.39 | 0.959 |
| 24 h (n = 25) | 0.09 | − 0.33 to 0.48 | 0.675 |
| 48 h (n = 24) | 0.17 | − 0.26 to 0.54 | 0.428 |
| Max (n = 26) | 0.17 | − 0.24 to 0.53 | 0.403 |
| CRP [mg/L] | |||
| Adm (n = 25) | 0.43 | 0.03 to 0.71 | 0.030 |
| 24 h (n = 18) | 0.59 | 0.16 to 0.84 | 0.009 |
| 48 h (n = 17) | 0.63 | 0.19 to 0.86 | 0.008 |
| Max (n = 26) | 0.27 | − 0.15 to 0.60 | 0.190 |
ACR = albumin to creatinine ratio, α1-MG = α1-microglobulin, CI = confidence interval, CRP = C-reactive protein, dpo = days post onset of first symptoms, IgG = immunoglobulin G, r = correlation coefficient, S-Alb = serum albumin, SCr = serum creatinine.
Bold values are statistically significant for p < 0.05.