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. 2020 Nov 5;10:19142. doi: 10.1038/s41598-020-76245-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Distributions of genome coverage and sequencing depth of the NIPT dataset. (a) Average genome coverage and sequencing depth per sample and from all samples combined. (b) Summary histogram of sequencing depth over all genome positions. (c) Distribution of sequencing depth per chromosome. (d) IGV tracks of sequencing depth, bwa MAPQ score, and Umap k50 mappability across the whole genome (the figure was produced using IGV, Integrative Genomics Viewer, version 2.8.9²⁴).