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. 2020 Nov 5;10:379. doi: 10.1038/s41398-020-01065-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A, B There is no change in the frequency (A) or amplitude (B) of the excitatory spontaneous postsynaptic current of Nes-cre; Rbm8a^fl/+ mice. Spontaneous excitatory postsynaptic current recordings from putative pyramidal cells in the somatosensory cortex, Student’s t test, n = 7–12. C Representative glutamate traces from control and cKO mice. D, E There is a significant decrease in the frequency (D), but not the amplitude (E) of the spontaneous inhibitory postsynaptic current in Nes-cre; Rbm8a^fl/+ mice. Spontaneous inhibitory postsynaptic current recordings from putative pyramidal cells in the somatosensory cortex, *p < 0.05, n > 7, Student’s t test. F Representative GABA trace from control and cKO mice. Bar graphs represent means ± SEMs. G Western blot showed a significant reduction of GABA-A receptor β3 subunit. *p < 0.05; n = 3, Student’s t test. Bar graphs represent means ± SEMs. H Western blot showed a no significant reduction of GAD67. n = 3, Student’s t test. Bar graphs represent means ± SEMs.