Table 2.

Components of the original TSE framework.

TSE component		Description
	Health impact	To what extent does the vaccine presentation protect against disease? Indicator: efficacy; effectiveness; factors affecting potency and timeliness of vaccination; duration of protection
Impact	Coverage	How does the vaccine presentation affect the proportion of the target population receiving the full vaccination schedule? Could the vaccine presentation decrease equity gaps in immunisation? Indicator: incremental coverage improvement (indicated by: vaccination schedule, storage requirements, administration requirements, acceptability, doses per container)
	Safety	Does the vaccine presentation have a lower safety risk? Indicator: adverse events following immunisation (AEFI); risk of programmatic error (incorrect preparation, contamination, incorrect delivery, needle-stick injury)
Cost	Commodity cost	What is the cost of the vaccine and supplies, for complete vaccination factoring in wastage? Indicator: vaccine cost, delivery technology cost, safety box cost
	Vaccine delivery cost	What are the operational costs to deliver the vaccine? Indicator: storage cost, transport cost, administration cost, waste disposal cost, monitoring and evaluation, introduction cost (including training, storage expansion, social mobilisation/communication)