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. 2020 Nov 5;10:19134. doi: 10.1038/s41598-020-76203-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Feature importance analysis. (A) DeepZ-predicted significant DNA motif (B) List of DNA-motifs for known TFs showing significant similarity to DeepZ motif (motifs are generated with Tomtom⁴⁸ from The MEME suit⁴⁹) (C). Positive and negative normalized regularization coefficients (top-20 positive and top-20 negative are presented, the full list can be found in Supplementary Table S3). Networks are generated with ShinyGO⁴⁴.