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. 2020 Nov 5;10:19111. doi: 10.1038/s41598-020-75776-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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(a) Difference in BDI score between participants with subclinical hypothyroidism and euthyroid participants after the first available follow up*. (b) Difference in BDI score between participants with subclinical hyperthyroidism and euthyroid participants after the first available follow up*. * Analysis adjusted for depressive symptoms at baseline, sex, age, and education (The CHS, Health ABC Study, and the InChianti Study were additionally adjusted for income). Overall mean BDI score at first follow-up was 10.67 with a standard deviation of 8.99. Abbreviations: SHypo Subclinical Hypothyroidism; SHyper Subclinical Hyperthyroidism; Leiden 85+ (9) Leiden 85 plus Study; PROSPER (7) Prospective Study of Pravastatin in the Elderly at risk; Health ABC Study (40) The Health, Ageing and Body Composition Study; CHS (26) Cardiovascular Health Study; InChianti Study (41) Invecchiare in Chianti Study; HUNT (42) Nord-Trøndelag Health Study; BDI Beck Depression Inventory Score (range 0–63, minimal clinically important difference 5 points); MD Mean Difference; CI Confidence Interval, No. Number.