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. 2020 Nov 5;10:19111. doi: 10.1038/s41598-020-75776-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Secondary outcomes—association between subclinical hypothyroidism and depressive symptoms*. * Analysis adjusted for depressive symptoms at baseline, sex, age, and education (The CHS, Health ABC Study, and the InChianti Study were additionally adjusted for income). † Analysis includes the same studies as for the primary outcome analysis: Leiden 85+ (9), PROSPER (7), Health ABC Study (40), CHS (26), InChianti Study (41), HUNT (42). ‡ Analysis includes the same studies as in the primary outcome analysis except of HUNT (42). § Analysis includes the same studies as in the primary outcome analysis plus the HIMS (30) which only had data on incidence of depression and no continuous measurement. Abbreviations: SHypo Subclinical Hypothyroidism; MD Mean Difference; BDI Score Beck Depression Inventory Score (range 0–63, minimal clinically important difference 5 points); CI Confidence Interval; No. Number.