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. 2020 Oct 23;8:554565. doi: 10.3389/fbioe.2020.554565

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Copyright © 2020 de Melo Pereira, Eischen-Loges, Birgani and Habibovic.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Alkaline phosphatase (ALP) activity of hMSC, normalized to cell number. Cells were cultured on tissue culture plastic (TCP) control, collagen (Col), and biomineralized collagen (BiominCol) for 3, 7, 14, and 21 days. Data are represented as mean ± SD (n = 6). Data under the limit of detection are denominated as <L.O.D (growth medium and collagen at day 3), and missing data is labeled as N.A. (TCP control at day 21). Data is presented as mean and standard deviation and significance is denoted as ***p < 0.001.