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Schematic representation of the microfluidic lung-on-chip (LOC) system. Cross-section through the LOC model displaying the upper chamber consisting of human lung epithelial cells and the lower chamber consisting of pulmonary endothelial cells divided by a thin porous membrane. Side vacuum channels stretch out the membrane and mimic in vivo breathing-like forces (adapted from Huh et al., 2010 and made in ©BioRender - biorender.com).
