Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Oct 23;10:595029. doi: 10.3389/fcimb.2020.595029

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 Augenstreich and Briken.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Model of the mechanism of membrane lysis by the cooperation of ESX-1 and PDIM. ESX-1 secretes EsxA and EsxB in a 1:1 heterodimer. This dimer is separated upon pH decrease and / or post-translational modifications, and free EsxA can induce pore formation. PDIM can potentiate EsxA membranolytic activity by either synergizing the pore forming activity of EsxA or by acting on the EsxA/B heterodimer complex separation.