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. 2020 Oct 23;10:595029. doi: 10.3389/fcimb.2020.595029

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Copyright © 2020 Augenstreich and Briken.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Models of mycobacterial envelope and lipid transfer. (Left) Simplified model of the organization of the mycobacterial envelope with the main virulence lipids highlighted. (Right) Representation of the different potential mechanisms of lipid release and transfer to the host cell membrane. Lipids can be release by emission of membrane vesicles, or by shedding of the capsular layer into the phagosome lumen or due to close physical contact directly into the phagosome membrane. SL, Sulfolipids; PDIM, Phthiocerol Dimycerosates; TDM, Trehalose Dimycolates; MA, Mycolic Acid; LAM, Lipoarabinomannan.