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. 2020 Oct 23;7:554597. doi: 10.3389/fcvm.2020.554597

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Copyright © 2020 Majid, Fricker, Gregory, Davidenko, Hernandez Cruz, Jabbour, Owen, Basnett, Lukasiewicz, Stevens, Best, Cameron, Sinha, Harding and Roy.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Macroscopic images of (A) Decellularized porcine valves impregnated with P(4HB) and implanted into the pulmonary position of sheep for 12 weeks display viability and retain the overall structure of the valve (263). (B) A tissue engineered heart valve derived from PGA, coated with P(4HB) and subsequently seeded with either adult stem cells or vascular cells. It has been placed into a self-expanding stent and is to be delivered to the pulmonary position of sheep for 8 weeks (264). (C) Aortic grafts derived solely from P(4HB) following molding using a CT generated structure of a human aortic valve. SV highlights the Sinus of Valsalva (265). (D) Solvent cast film derived from MCL-PHAs that has been utilized for LV cardiac regeneration (266, 267).