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. 2020 Oct 23;11:550674. doi: 10.3389/fmicb.2020.550674

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Copyright © 2020 Velazquez-Salinas, Zarate, Eberl, Gladue, Novella and Borca.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pairwise distance analysis. Pairwise distance analysis at (A) synonymous and (B) non-synonymous nucleotide sites was conducted using the program Sequence Distances (software SSE). Red bars represent pairwise distance comparisons using a sliding window of 50 nucleotides. Average nucleotide pairwise distance for different genes is shown at (C) synonymous and (D) non-synonymous sites. (E) Fast-evolving synonymous and non-synonymous sites at each coding region are shown. For these sites, evolutionary rates oscillated between 4.97 and 4.95. Red numbers represent nucleotides at: (1) leader protein, (2) nsp2, (3) nsp3, (4) nsp4, (5) nsp6, (6) nsp7, (7) nsp8, (8) nsp10, (9) RNA independent polymerase, (10) helicase, (11) 3' to 5' exonuclease, (12) endoRNAse, and (13) 2'-O-ribose methyltransferase.