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A scheme of the crypt-villus morphogenesis during tissue regeneration. Intestinal epithelium lost by intestinal injuries (STEP1) is rapidly re-epithelialized by wound-associated cell (WAE) monolayer (orange color; STEP2). Morphological transformation of the WAE monolayer into crypt-villus structure is initiated by WNT5A+ mesenchymal cells (STEP3) that subsequently develop to fully reconstitute the epithelium (STEP4).
