Table 3.
The neural specific pathways of genome wide DNA methylation microarray in patients with different addictive qualities.
| Pathway name | Diffgene count | Gene count | Enrichment | P-value | FDR |
|---|---|---|---|---|---|
| Circadian entrainment | 10 | 97 | 8.30 | 1.54E-06 | 3.21E-04 |
| Cholinergic synapse | 10 | 113 | 7.12 | 6.38E-06 | 6.57E-04 |
| Glutamatergic synapse | 10 | 118 | 6.82 | 9.48E-06 | 6.57E-04 |
| Retrograde endocannabinoid signaling | 9 | 103 | 7.03 | 2.35E-05 | 1.22E-03 |
| GABAergic synapse | 8 | 90 | 7.15 | 6.85E-05 | 2.85E-03 |
| Morphine addiction | 8 | 93 | 6.92 | 8.71E-05 | 3.02E-03 |
| PI3K-Akt signaling pathway | 14 | 347 | 3.25 | 5.31E-04 | 0.02 |
Diffgene count: differentially methylated gene count.
All the DMRs of genome wide DNA methylation microarray in the pairwise comparisons of the three groups were entered into the KEGG pathway analysis, which showed that seven pathways were statistically significant (FDR < 0.05 and p < 0.05) and associated with nervous system or neuronal function.