TABLE 1.
Volumes of the substantia nigra pars reticulata (SNpr), substantia nigra pars compacta (SNpc), and ventral tegmental area (VTA) in adolescence (postnatal day 35, P35) and adulthood (postnatal day 60, P60).
A/P coordinate 4.60–5.10 mm from bregma | A/P coordinate 5.20–5.70 mm from bregma | A/P coordinate 5.80–6.30 mm from bregma | |||
Volume (mm3) | Volume (mm3) | Volume (mm3) | |||
SNpr | SNpr | SNpr | |||
P35 day | P35 day | P35 day | |||
Control | 0.45 ± 0.03 | Control | 0.46 ± 0.02 | Control | / |
MD | 0.68 ± 0.06 | MD | 0.81 ± 0.12 | MD | / |
P60 day | P60 day | P60 day | |||
Control | 0.51 ± 0.01 | Control | 0.68 ± 0.04 | Control | / |
MD | 0.59 ± 0.02 | MD | 0.79 ± 0.01 | MD | / |
SNpc | SNpc | SNpc | |||
P35 day | P35 day | P35 day | |||
Control | 1.02 ± 0.05 | Control | 1.07 ± 0.07 | Control | 0.30 ± 0.01 |
MD | 1.74 ± 0.25 | MD | 2.11 ± 0.18 | MD | 0.73 ± 0.03 |
P60 day | P60 day | P60 day | |||
Control | 1.37 ± 0.03 | Control | 1.61 ± 0.08 | Control | 1.39 ± 0.08 |
MD | 1.83 ± 0.09 | MD | 2.02 ± 0.04 | MD | 1.78 ± 0.14 |
VTA | VTA | VTA | |||
P35 day | P35 day | P35 day | |||
Control | 1.06 ± 0.06 | Control | 1.35 ± 0.15 | Control | 0.59 ± 0.02 |
MD | 1.98 ± 0.13 | MD | 2.40 ± 0.26 | MD | 1.10 ± 0.16 |
P60 day | P60 day | P60 day | |||
Control | 1.23 ± 0.02 | Control | 1.69 ± 0.04 | Control | 1.43 ± 0.04 |
MD | 2.12 ± 0.11 | MD | 2.43 ± 0.10 | MD | 1.75 ± 0.08 |
All results are presented as mean values ± SEM. Numbers in bold are statistically significant mean values at p ≤ 0.05.