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. 2020 Oct 23;10:554521. doi: 10.3389/fonc.2020.554521

Table 2.

Inflammatory markers cut determination.

SII cut Cox HR (95% CI) p-value Harrell's C Somers' D
400 2.252 (1.358–3.735) 0.002 0.600 0.199
500 2.251 (1.465–3.460) <0.001 0.617 0.234
600 2.261 (1.496–3.418) <0.001 0.624 0.248
650 2.270 (1.509–3.413) <0.001 0.622 0.244
700 2.343 (1.559–3.520) <0.001 0.624 0.248
750 2.220 (1.477–3.335) <0.001 0.618 0.236
800 2.300 (1.529–3.460) <0.001 0.618 0.236
900 2.214 (1.462–3.353) <0.001 0.607 0.214
1,000 1.927 (1.249–2.972) 0.003 0.585 0.171
NLR cut Cox HR (95% CI) p-value Harrell's C Somers' D
2.00 2.368 (1.452–3.860) <0.001 0.602 0.204
2.35 2.335 (1.519–3.489) <0.001 0.621 0.241
2.40 2.410 (1.568–3.704) <0.001 0.625 0.250
2.45 2.343 (1.530–3.589) <0.001 0.623 0.246
2.50 2.363 (1.551–3.600) <0.001 0.626 0.252
2.55 2.226 (1.471–3.368) <0.001 0.623 0.247
2.60 2.156 (1.430–3.251) <0.001 0.619 0.238
2.70 2.190 (1.445–3.293) <0.001 0.620 0.240
2.75 2.176 (1.448–3.271) <0.001 0.621 0.242
2.80 2.228 (1.483–3.347) <0.001 0.625 0.251
2.85 2.206 (1.468–3.316) <0.001 0.618 0237
2.90 2.206 (1.468–3.316) <0.001 0.618 0.237
3.50 2.075 (1.373–3.137) <0.001 0.606 0.211
LMR cut Cox HR (95% CI) p-value Harrell's C Somers' D
3.0 0.663 (0.423–1.037) 0.072 0.550 0.100
3.5 0.570 (0.379–0.856) 0.007 0.579 0.158
4.0 0.482 (0.321–0.726) <0.001 0.605 0.210
4.3 0.454 (0.300–0.689) <0.001 0.613 0.226
4.5 0.445 (0.290–0.680) <0.001 0.617 0.233
4.6 0.445 (0.290–0.681) <0.001 0.617 0.233
4.7 0.422 (0.274–0.650) <0.001 0.622 0.244
4.8 0.454 (0.295–0.700) <0.001 0.612 0.224
4.9 0.452 (0.292–0.699) <0.001 0.612 0.225
5.0 0.482 (0.311–0.749) 0.001 0.603 0.206
5.5 0.466 (0.283–0.765) 0.003 0.587 0.173

NLR, neutrophil-to-lymphocyte ratio; HR, hazard ratio; LMR, lymphocyte-to-monocyte ratio; SII, systemic immune-inflammation index; CI, confidence interval. Bold values represent the optimal cut off point whose C-index is the highest.