Table 5.

Predictors of overall survival.

Cox for OS variablea	Univariate analysis		Multivariate analysisc
	HR (95% CI)	p-value	HR (95% CI)	p-value
Age
<60≥60	1.458 (0.9,424−2.256)	0.090	1.511 (0.957–2.386)	0.077
Sex (male)	0.904 (0.598–1.365)	0.631	–	–
aCCI	0.991 (0.877–1.120)	0.885	–	–
Tbil*
<34≥34	2.820 (1.673–4.752)	<0.001	1.073 (0.569–2.022)	0.828
Alb*
<35≥35	0.506 (0.308–0.832)	0.007	1.064 (0.579–1.954)	0.842
SII*
<600≥600	2.261 (1.496–3.418)	<0.001	1.694 (1.069–2.684)	0.024
NLR*
<2.5≥2.5	2.363 (1.551–3.600)	<0.001	1.170 (0.607–2.253)	0.639
LMR*
<4.7≥4.7	0.422 (0.274–0.650)	<0.001	0.931 (0.509–1.702)	0.817
CA 19-9*
<37≥37	3.648 (2.329–5.713)	<0.001	2.407 (1.472–3.933)	<0.001
AJCC stage*b		<0.001		0.026
0	<0.001	0.966	<0.001	0.994
I	0.075 (0.018–0.319)	<0.001	0.144 (0.032–0.641)	0.011
II	0.112 (0.038–0.326)	<0.001	0.227 (0.073–0.704)	0.010
III	0.518 (0.322–0.833)	0.007	0.693 (0.419–1.147)	0.154
IV	Indicator		Indicator

aCCI, age-adjusted Charlson Comorbidity Index; Tbil, total bilirubin; Alb, albumin; NLR, neutrophil-to-lymphocyte ratio; LMR, lymphocyte-to-monocyte ratio; SII, systemic immune-inflammation index; CA, carbohydrate antigen; AJCC, American Joint Committee on Cancer. The bold values represent that P value is less than 0.05.

^*indicates variables included in the multivariate model.

^aThe total number of this model is N = 142.

^bAJCC stage IV (n = 27) was selected as the indicator of the multiclass variable.

^cC-index of the multivariate model is 0.752.