Table 3.
Univariate and adjusted associations of frailty status (non-frail, pre-frail, frail) with fractional anisotropy of white matter regions of interest (ROIs).
| White matter ROIs | Univariate associations | Adjusted associations |
|---|---|---|
| β (95% CI) | β (95% CI) | |
| Genu of the corpus callosum | -0.511 (-0.643,−0.380) | −0.098 (-0.232, 0.036) |
| Body of the corpus callosum | -0.496 (-0.628,−0.363) | -0.164 (-0.305,−0.023) |
| Splenium of the corpus callosum | -0.421 (-0.554,−0.287) | −0.114 (-0.258, 0.029) |
| Uncinate fasciculus | -0.161 (-0.301,−0.022) | −0.055 (-0.210, 0.100) |
| Superior longitudinal fasciculus | -0.135 (-0.270, 0.0002) | 0.024 (-0.128, 0.176) |
| Inferior fronto-occipital fasciculus | -0.287 (-0.422,−0.152) | −0.071 (-0.222, 0.079) |
| Superior fronto-occipital fasciculus | -0.355 (-0.488,−0.222) | -0.166 (-0.313,−0.018) |
| Anterior limb of internal capsule | -0.341 (-0.478,−0.205) | −0.101 (-0.249, 0.047) |
| Posterior limb of internal capsule | -0.084 (-0.221, 0.054) | −0.021 (-0.171, 0.129) |
| External capsule | -0.319 (-0.453,−0.185) | −0.001 (-0.146, 0.143) |
| Posterior thalamic radiation | -0.237 (-0.372,−0.101) | −0.121 (-0.275, 0.033) |
| Anterior of corona radiate | -0.496 (-0.627,−0.366) | −0.091 (-0.224, 0.043) |
| Superior of corona radiate | -0.219 (-0.355,−0.083) | −0.064 (-0.217, 0.089) |
| Posterior of corona radiate | −0.032 (-0.168, 0.104) | 0.005 (-0.148, 0.158) |
| Cingulum hippocampal part | -0.211 (-0.346,−0.075) | 0.033 (-0.113, 0.179) |
| Cingulum cingulate part | -0.270 (-0.404,−0.136) | −0.008 (-0.150, 0.135) |
Adjusted associations controlled for age, sex, race, education, BMI, and APOE e4. Bold numbers indicate associations at p ≤ 0.05. Fractional anisotropy values were standardized Z scores.