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. 2020 Oct 23;11:1725. doi: 10.3389/fimmu.2020.01725

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Copyright © 2020 Keshavarzian, Noroozbeygi, Haji Molla Hoseini and Yeganeh.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Determination of humoral immune response in mice. Total IgG1 and total IgG2a levels were measured two times using ELISA. Mice were bled 3 and 8 weeks after challenge with L. major^EGFP. (A) IgG1 levels before and after challenge. The level of IgG1 significantly decreased in immunized mice (ILL and ILL+CpG groups), after the challenge. (B) IgG2a levels before and after the challenge. After the challenge, the level of IgG2a was increased significantly only in the ILL+CpG group. (C) IgG2a/IgG1 ratio levels before and after challenge. The IgG2a/IgG1 ratios were increased in ILL+CpG after challenge. Mann–Whitney U-test was performed to compare antibody levels before and after the challenge of each group and significant differences are shown with asterisks (*P ≤ 0.05). Data are shown as mean ± SD. I.L.L (Iranian Lizard Leishmania), ILL+CpG (Iranian Leishmania Lizard+CpG).