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Strategies to improve tumor perfusion increase tumor immunogenicity. Angiogenesis, desmoplasia, and inflammation promote leaky and compressed tumor vessels. Vascular normalization strengthens the vessel wall reducing intercellular gaps and improving perfusion. Blood vessel decompression by depletion of CAFs or ECM reperfuses the vessel and augments perfusion. As a result, reprogramming of the TME to an immunomodulatory state enhances antitumor immunity.
