Table 2.
Association analysis of rs17016188 and rs7684892 with PD risk.
| Variant | Allele, n (%) | OR (95% CI) | p | Genotype, n (%) | p | |||
|---|---|---|---|---|---|---|---|---|
| rs17016188 | T | C | TT | CT | CC | |||
| Control | 669 (66.0) | 345 (34.0) | 223 (44.0) | 223 (44.0) | 61 (12.0) | |||
| PD | 634 (61.8) | 392 (38.2) | 1.199 (1.001–1.437) | 0.049 | 207 (40.4) | 220 (42.9) | 86 (16.8) | 0.089 |
| Male control | 388 (67.6) | 186 (32.4) | 127 (44.3) | 134 (46.7) | 26 (9.1) | |||
| Male PD | 313 (59.3) | 215 (40.7) | 1.433 (1.120–1.833) | 0.004* | 99 (37.5) | 115 (43.6) | 50 (18.9) | 0.003* |
| Female control | 281 (63.9) | 159 (36.1) | 96 (43.6) | 89 (40.5) | 35 (15.9) | |||
| Female PD | 321 (64.5) | 177 (35.5) | 0.974 (0.746–1.273) | 0.850 | 108 (43.4) | 105 (42.2) | 36 (14.5) | 0.884 |
| rs7684892 | G | A | GG | AG | AA | |||
| Control | 824 (81.3) | 190 (18.7) | 335 (66.1) | 154 (30.4) | 18 (3.6) | |||
| PD | 798 (77.8) | 228 (22.2) | 1.239 (0.999–1.537) | 0.051 | 312 (60.8) | 174 (33.9) | 27 (5.3) | 0.149 |
| Male control | 474 (82.6) | 100 (17.4) | 196 (68.3) | 82 (28.6) | 9 (3.1) | |||
| Male PD | 409 (77.5) | 119 (22.5) | 1.379 (1.025–1.856) | 0.033 | 163 (61.7) | 83 (31.4) | 18 (6.8) | 0.079 |
| Female control | 350 (79.6) | 90 (20.5) | 139 (63.2) | 72 (32.7) | 9 (4.1) | |||
| Female PD | 389 (78.1) | 109 (21.9) | 1.090 (0.796–1.492) | 0.592 | 149 (59.8) | 91 (36.8) | 9 (3.6) | 0.680 |
CI, confidence interval; OR, odds ratio; PD, Parkinson’s disease.
*
Indicates p < 0.025 after Bonferroni correction.