Table 2.
CGM system | Glucose sensing methods | Technical features4 | Known interferences from chemical substances |
---|---|---|---|
Abbott Diabetes Care FreeStyle Libre 14 day system28 | GO + Redox Sensing Membrane | No required calibration; warm-up 1 hour; 14 days of sensor wear; range 40-500 mg/dL; no predictive alerts; requires scanning at least every 8 hours | Ascorbic acid Salicylic acid |
Abbott Diabetes Care FreeStyle Libre 229,30 | GO + Redox Sensing Membrane | No required calibration; warm-up 1 hour; 14 days of sensor wear; range 40-400 mg/dL; no predictive alerts; optional alarms for hypoglycemia, hyperglycemia, and signal loss; requires scanning at least every 8 hours | Ascorbic acid |
Dexcom G631,32 | GO + Perm-selective membrane coating | No required calibrations; warm-up 2 hours; 10 days of sensor wear; range 40-400 mg/dL; hypoglycemia predictive alerts | Hydroxyurea |
Medtronic MiniMed Guardian Sensor 334,35 | GO | Requires 2-4 calibrations/day; warm-up 2 hours; 7 days of sensor wear; range 40- 400 mg/dL; predictive alerts | Acetaminophen |
Senseonics Eversense36,37 | Nonenzymatic electrochemical fluorescent-based polymer | Required 2 calibrations/day; implantable; warm-up 24 hours; 90-180 days of sensor wear; predictive alerts for hypoglycemia and hyperglycemia; conditional MRI compatibility |
Mannitol Tetracycline |
GO, glucose oxidase; MRI, magnetic resonance imaging.